The Association Between Obesity-Related Indicators and Adverse Outcomes in Ischemic Stroke Patients

This study encompasses two cohorts: a retrospective cohort derived from a genuine clinical environment and a national multicenter prospective cohort for secondary analysis. Initially, a retrospective cohort study was conducted to investigate the impact of metabolic syndrome on the prognosis of stroke patients. Following this, a prospective cohort study was conducted to examine the relationships among metabolic syndrome, potential causative molecules, and adverse outcomes in stroke patients, as previously reported(Annals of Neurology 2011, 70(2):265-273; Lipids in Health and Disease 2024, 23(1)). Additionally, the study explored potential mediating effects among these factors. The study population comprised patients experiencing acute first-ever ischemic stroke, with diagnostic criteria established according to the International Classification of Diseases, Ninth Revision. All subjects presented conclusive neuroimaging evidence, including head computed tomography and/or magnetic resonance imaging, which was reviewed by two or more experienced neuroradiologists. Adverse outcomes were characterized as compliant endpoint events, including mortality and recurrences. The primary outcome was adverse outcomes, while the secondary outcome was recurrence-free survival (RFS).