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NMDA Modulation in Antidepressant Nonresponders With Major Depressive Disorder

China Medical University Hospital · 2022
ClinicalTrials.gov · Datasets · License: Public Domain · 2022
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major-depressive-disorder
Most of the current antidepressants for major depressive disorder (MDD) are based upon the monoamine hypothesis which cannot fully explain the etiology of depression. NMDA hypofunction has been implicated in the pathophysiology of depression. This study aims to examine the efficacy and safety of an NMDA enhancer (NMDAE) in the treatment of antidepressant nonresponders with MDD.
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