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Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors
advanced-solid-tumorsbreast-cancergastric-cancerhead-and-neck-squamous-cell-carcinomansclcovarian-cancerpancreatic-ductal-adenocarcinoma
The purpose of this first-in-human (FIH) study is to evaluate the safety, tolerability, Pharmacokinetics (PK), and preliminary clinical activity of M7437 in participants with locally advanced or metastatic solid tumors with known Ly6E expression, including non-small cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), epithelial ovarian carcinoma (EOC), squamous cell carcinoma of the head and neck (SCCHN), pancreatic ductal adenocarcinoma (PDAC), and gastric cancer (GC).
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