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Adrenal Cortical Function and Vitamin A Deficiency in Sepsis

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · 1993
ClinicalTrials.gov · Datasets · License: Public Domain · 1993
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sepsis
The study involves the participant to receive a 250 mcg Cortrosyn (ACTH) Stimulation Test to test the ability of the body to make Cortisol. If the body is not able to make large amount of Cortisol (Delta Cortisol \ 13 mg/dl), then the participant will receive daily shots of Vitamin A for 7 days or matching placebo. If the participant does not respond to the stimulation test, and meets the criteria for Cortisol deficiency (all 3 cortisol concentrations \< 20 mg/dl), then he/she will screen failed for the study and will be offered hydrocortisone as part of routine care by the treating physician.
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