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Infusion of Allogeneic CD19-Specific T Cells From Peripheral Blood

M.D. Anderson Cancer Center · 2011
ClinicalTrials.gov · Datasets · License: Public Domain · 2011
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acute-lymphoblastic-leukemiahematopoietic-stem-cell-transplantationleukemialymphoma
The goal of this clinical research study is to learn if researchers can successfully and safely give HSCT patients an infusion of white blood cells (called T-cells) that have been genetically changed. The process of changing the DNA (the genetic material in cells) of these T-cells is called "gene transfer." Researchers want to learn if these genetically-changed T-cells are effective in attacking cancer cells in patients with advanced B-cell lymphoma or leukemia, after they have received standard allogeneic HSCT. Researchers want to find out the highest dose of these special T-cells that can be given safely to leukemia and lymphoma patients. Researchers also want to learn how long the changed T-cells stay in your body, and if adding them to standard transplant can improve how you respond to treatment.
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