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TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
advanced-solid-tumorcancercervical-cancercolorectal-cancerendometrial-cancerhead-and-neck-squamous-cell-carcinomakidney-cancerovarian-cancer
TTX-080-001 is a Phase 1, open label, dose escalation and dose expansion clinical study to determine the safety, tolerability, and recommended Phase 2 dose of TTX-080 monotherapy (HLA-G inhibitor) and in combination with either pembrolizumab (PD-1 inhibitor), cetuximab (EGFR inhibitor) or FOLFIRI plus cetuximab (EGFR inhibitor) in patients with advanced refractory / resistant solid malignancies including metastatic colorectal cancer (mCRC) patients.
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