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The Relationship Between Central Sensitization, Pain, and Psychosocial Factors in Individuals With Lipedema

Istanbul Physical Medicine Rehabilitation Training and Research Hospital · 2025
ClinicalTrials.gov · Datasets · License: Public Domain · 2025
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This cross-sectional study will include women aged 18-75 with clinically diagnosed lipedema and healthy controls. Sociodemographic and clinical data will be collected, and participants will complete the Central Sensitization Inventory (CSI), Visual Analog Scale (VAS), Hospital Anxiety and Depression Scale (HADS), and Pain Catastrophizing Scale (PCS). Pain pressure thresholds (PPT) will be assessed using a digital algometer at the middle deltoid, lateral thigh, and medial knee, with three measurements taken at each site and the average recorded.
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