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Between the Belly and the Brain: Distorted Gut-brain Crosstalk in Early-life Adversity

Universitair Ziekenhuis Brussel · 2025
ClinicalTrials.gov · Datasets · License: Public Domain · 2025
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depressive-symptomsgut-microbiomemicrobiome
The goal of this observational study is to learn about the effects of early-life adversity (ELA) on the composition of children's microbiome and on their psychosocial functioning. The main questions it aims to answer are: * Do children who have experienced ELA have lower gut microbial diversity and/or an altered gut microbial composition? * Do these microbiome alterations correlate with adverse neurodevelopmental outcomes, including increased levels of stress, social and/or affective problems?
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