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Clinical Impact of an Anti-Inflammatory Diet in Anxiety and Depression With AI

Universidad de Zaragoza · 2026
ClinicalTrials.gov · Datasets · License: Public Domain · 2026
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anxietyartificial-intelligencedepressionna
The goal of this clinical trial is to evaluate the effectiveness of an anti-inflammatory dietary intervention on physical health, mental health, and cognitive functioning in individuals with clinically diagnosed anxiety and/or depression, and to assess the agreement between artificial intelligence-based analysis of verbal and non-verbal language patterns and standard psychometric assessment tools. The study will include adult participants (≥18 years) with a clinical diagnosis of anxiety and/or depressive disorder, irrespective of sex or gender. The main questions it aims to answer are: Does a 4-month anti-inflammatory dietary intervention improve mental health outcomes (anxiety and depressive symptoms) compared to a control condition in individuals with anxiety and/or depression? Does the intervention lead to improvements in physical health and cognitive functioning relative to the control group? Are verbal and non-verbal language patterns analyzed using artificial intelligence coherent with the results obtained from validated anxiety and depression questionnaires at baseline? Do changes in AI-derived language markers parallel changes in clinical and self-reported outcomes following the dietary intervention? Primary outcomes / hypotheses: Does the anti-inflammatory dietary intervention produce greater reductions in anxiety and depressive symptom severity compared to the control group after 4 months? Does the intervention result in significant improvements in physical health and cognitive performance compared to the control group? Researchers will compare the anti-inflammatory diet intervention group with the control group (usual diet or standard dietary advice) to determine whether the intervention leads to superior improvements in mental, physical, and cognitive health outcomes. Participants will: Complete baseline assessments including validated questionnaires on anxiety, depression, physical health, cognitive functioning, and quality of life. Undergo
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