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Combination Therapy Using Durvalumab and Histotripsy for Treatment of Intrahepatic Cholangiocarcinoma

University of Wisconsin, Madison · 2026
ClinicalTrials.gov · Datasets · License: Public Domain · 2026
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immunotherapyintrahepatic-cholangiocarcinomatumor-microenvironment
The purpose of this research is to evaluate whether adding histotripsy to maintenance durvalumab increases immune response and to assess the safety of this combination for participants with advanced intrahepatic cholangiocarcinoma (iCCA). Histotripsy is a non-invasive, non-thermal treatment that uses focused ultrasound energy to destroy tumor tissue. 12 people will be enrolled in this study.
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