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Trial of Exercise to Prevent HypeRtension in Young Adults

University of Oxford · 2016
ClinicalTrials.gov · Datasets · License: Public Domain · 2016
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TEPHRA investigates the effect of exercise on blood pressure and other cardiovascular factors in young adults with different birth histories. TEPHRA will recruit 200 participants from 18-35 years old with elevated blood pressure (100 participants pre-term born and 100 full-term born). Half of the participants from each birth group will be randomised into a 16 week supervised aerobic exercise intervention trial and the other half will be controls. Participants will complete 3 main study visits: * Visit 1: Baseline visit conducted at beginning of study * Visit 2: 16 weeks into study (upon completion of structured exercise intervention for the exercise group) * Visit 3: End of study (52 weeks) Each visit will repeat the same set of cardiovascular measures including CPET, echo, blood pressure, vascular stiffness, and other measures. 50 participants from each group will complete an MRI sub-study of the heart, brain, and liver.
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