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Stability of Driving Pressure Changes During "Best Positive End Expiratory Pressure (PEEP)" Trial

University of Alabama at Birmingham · 2024
ClinicalTrials.gov · Datasets · License: Public Domain · 2024
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acute-respiratory-distress-syndromeacute-respiratory-failure
The goal of this study is to better understand in changes in lung compliance as indicated by driving pressure (a non-invasive marker) following changes in positive end expiratory pressure (PEEP; a standard of care ventilator parameter). The main question it aims to answer is: The time to stability of driving pressure after a change in PEEP is made Type of study: observational study participant population/health conditions Participants will undergo a "best PEEP trial" which is a standard intensive care intervention for patients undergoing invasive mechanical ventilation. This involves changing the patient's PEEP and looking for response in driving pressure. This will be done in a more protocolized format and data will be collected.
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