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A Biospecimen Collection Study in BRAF-V600E Mutated Recurrent Gliomas

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · 2018
ClinicalTrials.gov · Datasets · License: Public Domain · 2018
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glioblastomaglioma
This is a surgical biospecimen collection study. The purpose of this study is to understand how much of two drugs (dabrafenib and trametinib) are able to penetrate brain tumors and turn off the RAF signaling pathway. This is important because these drugs are currently FDA approved for other tumors and may have efficacy in brain tumors with the BRAF V600E mutation.
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