Study of the Effects of Supplements on Eye Disease in Participants From the Age-Related Eye Disease Study

Background: \- The Age-Related Eye Disease 2 Study (AREDS2) looked at two eye diseases. These were age-related macular degeneration (AMD) and cataracts. Participants in that study took supplement pills and some participants had additional pictures taken of their eyes. That study is now over. Researchers want to do a follow-up study after participants finish taking the pills, to see if they cause long-term effects on AMD. This study will be combined with follow-up visits of the AREDS2 study if possible. Objectives: \- To learn more about the effect of oral supplements on AMD. Eligibility: \- People who completed the AREDS2 study. Design: * Participants will have up to 2 study visits over 6 18 months. * Each visit will last up to 5 hours. The visits will be combined with annual follow-up visits in the AREDS2 study if possible. * At each visit, participants will undergo an eye exam and photography. * The eye exam includes testing sight, measuring eye pressure, and checking eye movements. To examine the inside of the eye, the pupil will be dilated with eye drops. * Photographs of the inside of the eye may be taken during the eye exam and while the eyes are dilated. * A contact lens may be placed on the eye briefly to look at the retina at the back of the eye.