Clinical and Radiographic Evaluation of NIPSA Versus M-MIST in Treatment of Intra-osseous Defects

The aim: Clinical and Radiographic Evaluation for intra-osseous defects in stage III periodontitis using NIPSA versus M-MIST Steps in short Pre-surgical therapy • Before surgical intervention, each patient will be given careful instructions on proper oral hygiene measures. Surgical Procedures: * Group B (Control): Patients will receive Modified Minimally Invasive Surgical technique (M-MIST) Group A (Test): Patients will receive Non-Incised Papilla Surgical Approach (NIPSA) Postoperative medication * Administration of amoxicillin (500 mg tabs) T.I.D for 7 days and Metronidazole (500 mg tabs) T.I.D for 7 days * Rinsing with Chlorhexidine 0.12% (B.I.D for 14 days). * Ibuprofen 600 mg tabs once every 8h could be administrated in case of unbearable pain * Follow up period: after 8 weeks/ after surgery by 1 week- 1 month- 3 months- 6 months- 1 year