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Detailed Assessment of Augmented Renal Clearance in a Large Mixed Intensive Care Unit Population

Universitaire Ziekenhuizen KU Leuven · 2018
ClinicalTrials.gov · Datasets · License: Public Domain · 2018
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critical-illness
This multi-center retrospective cohort study presents a detailed assessment of augmented renal clearance (ARC) in a mixed population of adult critically ill patients. Epidemiology of ARC will be studied in detail in a very heterogeneous population. Risk factors for ARC will be identified and a predictive scoring system for ARC ready to use in clinical practice will be constructed and validated. Performance of estimators of kidney function will be measured and a cutoff for ARC will be determined for the best estimator. Finally clinical impact of ARC will be explored using vancomycine and aminoglycosides levels as surrogate marker.
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