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The Selective Personalized Radio-Immunotherapy for Locally Advanced Non-Small Cell Lung Cancer Trial 2

Montefiore Medical Center · 2026
ClinicalTrials.gov · Datasets · License: Public Domain · 2026
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biomarkersimmunotherapynon-small-cell-lung-cancerpatient-reported-outcomesradiotherapy
This is a randomized trial evaluating the efficacy and safety of sequential dual-agent immunotherapy and risk-adapted radiotherapy for patients with locally advanced non-small cell lung cancer (NSCLC) with a PD-L1 tumor proportion score of at least 50%. Participants will be randomized between two dual-agent immunotherapy regimens: durvalumab + monalizumab versus durvalumab + oleclumab.
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