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a Single-arm, Single-center, Open Clinical Study

Beijing Geekgene Technology Co., LTD · 2023
ClinicalTrials.gov · Datasets · License: Public Domain · 2023
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adverse-eventcell-therapycervical-cancerefficiencyesophageal-cancergastric-cancernon-small-cell-lung-cancer-nsclcsafety
This trial plans to enroll many patients with advanced solid tumors to complete GK01 cell transfusion, including but not limited to advanced gastric cancer, esophageal cancer, cervical cancer, triple-negative breast cancer, and non-small cell lung cancer. For patients with advanced solid tumors eligible for inclusion, autologous tumor-reactive T cells (experimental drug GK01) were cultured and prepared, and a certain dose of GK01 cells was given according to the cell transfusion plan, and the safety and tolerability of the patients after transfusion were observed. Exploratory evaluation of pharmacokinetic/pharmacodynamic profiles following reinfusion and initial evaluation of efficacy of investigational drug GK01 cells according to RECIST 1.1 criteria.
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