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Tamoxifen in Treatment of Acute Mania

Stanley Medical Research Institute · 2003
ClinicalTrials.gov · Datasets · License: Public Domain · 2003
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bipolar-disorderclinical-trial
Objective: Evidence indicates that the protein kinase C-PKC signaling cascade may be one of the direct targets in treatment of mania. The aim of this study is to investigate whether the PKC inhibitor-tamoxifen has anti-manic properties. Method: Bipolar subjects with manic/mixed episode were randomly assigned to receive either tamoxifen (80mg/day) or identical placebo tablets in 1:1 ratio for three weeks.
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