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Continuous Flow Br/Li Exchange Enables Scalable Synthesis of Chiral N, P Ligands for Asymmetric Catalysis
biochemistrybiophysicsbiotechnologycell-biologydevelopmental-biologyinfectious-diseasesmolecular-biologypharmacology
Chiral N, P ligands represent privileged scaffolds in asymmetric catalysis, yet their scalable synthesis suffers from traditional batch constraints: ultra-cryogenic conditions (−100 to −120 °C), competitive benzyne formation, low yields, and poor scalability. Herein, a concise continuous-flow
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