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Characterization of Tryptophan 2,3-dioxygenase in human melanoma cell lines and endothelial cells as a new therapeutic target
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are heme-enzymes involved in the degradation of tryptophan (Trp) into kynurenine (Kyn) within the kynurenine pathway (KP). While the role of IDO1 in cancer immune escape has been extensively studied, recent evidence suggests t
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