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Mitochondrial dysfunction plus high-sugar diet provokes a metabolic crisis that inhibits growth

Koc University Digital Collections · Papers · License: CC BY 4.0
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diseasedrosophila-melanogasterescherichia-coliexpressionmutationscience-and-technologytranslation
The Drosophila mutant tko(25t) exhibits a deficiency ofmitochondrial protein synthesis, leading to a global insufficiency of respiration and oxidative phosphorylation. This entrains an organismal phenotype of developmental delay and sensitivity to seizures induced bymechanical stress. We found that
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