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Binding induced conformational changes of proteins correlate with their intrinsic fluctuations: a case study of antibodies

Koc University Digital Collections · Papers
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antigenbiophysicsdynamicsenzymesite
Background: How antibodies recognize and bind to antigens can not be totally explained by rigid shape and electrostatic complimentarity models. Alternatively, pre- existing equilibrium hypothesis states that the native state of an antibody is not defined by a single rigid conformation but instead wi
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