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A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells
The cytosolic domain of Notch is a membrane-tethered transcription factor. Ligand binding ultimately leads to γ-secretase cleavage within the transmembrane domain, allowing the intracellular domain to translocate to the nucleus and activate target gene transcription. Constitutive Notch signaling has
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