Regulation of ryanodine receptor RyR2 by protein-protein interactions: prediction of a PKA binding site on the N-terminal domain of RyR2 and its relation to disease causing mutations

chemical and biological engineering, human; reflex latency determination; cumulated density; emg; averaging; cyclic amp dependent protein kinase; ryanodine receptor 2; amino terminal sequence; article; binding affinity; binding site; energy metabolism; gene mutation; genetic conservation; ligand binding; mathematical model; molecular docking; prediction; protein binding; protein protein interaction; protein structure; regulatory mechanism