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Estudo associativo entre a esquizofrenia e o polimorfismo G22A no gene da adenosina deaminase (ADA)
The purinergic system, especially adenosine, can play a role in the pathophysiology of schizophrenia. Activation of adenosine A1R inhibits the release of several neurotransmitters, such as glutamate, dopamine, serotonin and acetylcholine, and decreases neuronal activity by pos-synaptic hyperpolariza
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