Repositorio de Universidad Autónoma de Chile.
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Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome
Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles. Our laboratory recently demonstrated the disturbance of PI3K/AKT/mTOR axis in DS brain, prior and after the
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