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Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme
biological-engineeringcrystal-structuredegradationdynamicsenzymesin-vivoinhibitorsmultidisciplinary-sciences
Background: Insulin-degrading enzyme (IDE) is an allosteric Zn+2 metalloprotease involved in the degradation of many peptides including amyloid-beta, and insulin that play key roles in Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM), respectively. Therefore, the use of therapeutic agent
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