Computational design of new peptide inhibitors for amyloid beta (A beta) aggregation in Alzheimer's disease: application of a novel methodology

Alzheimer's disease is the most common form of dementia. It is a neurodegenerative and incurable disease that is associated with the tight packing of amyloid fibrils. This packing is facilitated by the compatibility of the ridges and grooves on the amyloid surface. The GxMxG motif is the major facto