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From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria
Background: The survival of malaria parasites, under substantial haem-induced oxidative stress in the red blood cells (RBCs) is dependent on the pentose phosphate pathway (PPP). The PPP is the only source of NADPH in the RBC, essential for the production of reduced glutathione (GSH) and for protecti
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