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CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.

Chang Gung Memorial Hospital · 2023
ClinicalTrials.gov · Datasets · License: Public Domain · 2023
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cerebrospinal-fluidmetabolomicsna
In this randomized control study, the investigators intended to evaluate the influence of different anesthetics on postoperative cognitive dysfunction, neuroinflammation, CSF metabolomics, and glymphatic function in patients with normal pressure hydrocephalus for VP shunt surgery. The investigators assume that the use of dexmedetomidine infusion and proper anesthsia depth during general anesthesia, in addition to multi-model analgesia, might be helpful to enhance glymphatic function, reduce neuroinflammation, and decrease postoperative cognitive dysfunction.
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