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Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations
Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a central regulator of immunity. TRAF3 is often somatically mutated in B cell malignancies, but its role in human immunity is not defined. Here, in five unrelated families, we describe an immune dysregulation syndrome of recurrent bacteri
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