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DeorphaNN: Virtual screening of GPCR peptide agonists using AlphaFold-predicted active-state complexes and deep learning embeddings

Ferguson, Larissa et al.
PubMed Central · Reports
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Peptide-activated G protein-coupled receptors (GPCRs) regulate physiological processes through interaction with neuropeptides and peptide hormones. Identifying endogenous peptide agonists remains challenging, as peptide-GPCR pairings often follow gene-family relationships that offer limited predicti
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