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Pairwise transmembrane domain insertion during multipass protein biogenesis

Smalinskaitė, Luka et al.
PubMed Central · Reports
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The ~2,500 multipass membrane proteins encoded in the human genome are constructed mostly or entirely of transmembrane domain (TMD) pairs: exceptionally common biosynthetic units comprised of two TMDs separated by a short non-cytosolic loop. It has long been thought that each TMD of a pair sequentia
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