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TRIM21 induces selective autophagy of viruses and bacteria

Rhinesmith, Tyler et al.
PubMed Central · Reports
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TRIM21 is an exceptionally versatile ubiquitin ligase that can be directed by antibodies to target oligomeric protein scaffolds, viral capsids, and proteopathic aggregates for intracellular degradation. How the cell degrades these typically resistant substrates remains poorly understood. To address
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