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Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes

Victor Chang Cardiac Research Institute · 2026
ClinicalTrials.gov · Datasets · License: Public Domain · 2026
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autoimmune-diseasesdiabetes-mellitusendocrine-system-diseasesglucose-metabolism-disordersinsulin-resistancemetabolic-diseasestype-1type-1-diabetes-mellitus
This study will examine the effects of Tirzepatide (TZP), a glucagon-like peptide 1 (GLP1) - gastric inhibitory peptide (GIP) co-agonist, on metabolism in type 1 diabetes (T1D). Research participants with T1D will undergo measures of insulin sensitivity, and hormone levels post-meal, post-hypoglycemia and during the overnight period. These measures will be performed prior to, and after 6 weeks of treatment with TZP or placebo.
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