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Efficacy of N-acetylcysteine With or Without Steroids in Drug Induced Liver Injury

Institute of Liver and Biliary Sciences, India · 2016
ClinicalTrials.gov · Datasets · License: Public Domain · 2016
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Intervention - Subjects will be randomized to 2 groups Group A - subjects will receive Prednisolone for 20 days with NAC (N-Acetylcysteine) Group B - will receive NAC (N-Acetylcysteine) only NAC (N-acetylcysteine) dosing Loading dose: 150 mg/kg IV; mix in 200 mL of 5% dextrose in water (D5W) and infuse over 1 hour Dose 2: 50 mg/kg IV in 500 mL D5W over 4 h Dose 3: 100 mg/kg IV in 1000 mL D5W over 16 h * Monitoring and assessment-Liver Biopsy at baseline and at 3 months, Liver Function Test at regular intervals. * Stopping rule-Development of sepsis, worsening of Liver functions.
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