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Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair

Wienert, Beeke et al.
eScholarship · Papers
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31-biological-sciences-for-2020
Repair of double strand DNA breaks (DSBs) can result in gene disruption or gene modification via homology directed repair (HDR) from donor DNA. Altering cellular responses to DSBs may rebalance editing outcomes towards HDR and away from other repair outcomes. Here, we utilize a pooled CRISPR screen
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