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Nickase and Cas9-induced Homologous Chromosome Templated Repair (HTR) in Drosophila and Mammalian systems
CRISPR-based genome editing holds great promise for many therapeutic applications; however, conventional Cas9 introduces double-strand breaks (DSBs) that can lead to large deletions and mutagenic off-target effects. In contrast, Cas9-derived nickases generate single-strand breaks (SSBs) and are asso
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