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Investigation of the cardiovascular effects of IGF-IR knockdown following systemic delivery of antisense oligonucleotides and small interfering RNA
The main aim of this body of work was to use gene silencing approaches to investigate the cardiovascular effects of Insulin-like growth factor (IGF-I) via the IGF-I receptor (IGF-IR). IGF-I has acute effects on cardiovascular function, including a well-characterised vasodilator response
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