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Detecting and explaining clinical-omics inconsistencies to improve patient cohort stratification: an application to Parkinson's disease
Discrepancies between clinical diagnoses and omics profiles within a characterized cohort may reflect misdiagnosis, hidden subgroups or prodromal disease states. We propose MLASDO, a tool to detect and characterize such discrepancies before downstream analyses. MLASDO (1) detects outliers using two
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