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2-(Piperidin-1-yl)-N-(4-sulfamoylphenyl)acetamide derivatives as novel inhibitors of cancer-associated carbonic anhydrase isoforms IX and XII
Overexpression of carbonic anhydrases IX and XII due to hypoxia contributes to tumor acidification and progression, suggesting that selective inhibitors may serve as effective anticancer agents. Thirteen piperidine-linked benzenesulfonamides (7a-k, 9, and 11) were synthesized and assessed for their
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