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NAALADL1 as a key modulator of resistance to Tumor Treating Fields therapy in colorectal cancer
Colorectal cancer (CRC) shows heterogeneous responses to Tumor Treating Fields (TTF), a non-invasive therapy disrupting mitosis. In 21 CRC cell lines, TTF induced microtubule disruption, mitotic defects, metabolic stress, DNA damage, and apoptosis. NAALADL1 was upregulated in resistant cells; its kn
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