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Investigating the Effect of the Monogenic Diabetes Gene HNF1A on Mitochondrial Metabolism in the Liver
While the cause of most diabetes is multifactorial, some cases result from single-gene mutations that impair pancreatic β-cell function, termed monogenic diabetes. The most common form is MODY3, caused by heterozygous mutations in the HNF1A transcription factor. Previous studies in our laboratory ha
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