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1,3,4-Oxadiazole derivatives as potential anti-glioma agents: synthesis, characterization, in vitro cytotoxic activity against HS683 cells, and molecular docking
The 1,3,4-oxadiazoles were synthesized by acid-catalyzed condensation of the hydrazides with aromatic aldehydes to give the hydrazones, which were then oxidized to the corresponding 1,3,4-oxadiazoles using I2/K2CO3 in DMSO. Characterization was carried out by FT-IR, 1H NMR, 13C NMR, and EI mass spec
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