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High-Dose Methotrexate in Treating Young Patients With Solid Tumors

Children's Cancer and Leukaemia Group · 2007
ClinicalTrials.gov · Datasets · License: Public Domain · 2007
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protocol-specificsarcoma
RATIONALE: Drugs used in chemotherapy, such as high-dose methotrexate work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Chemoprotective drugs, such as leucovorin calcium, may protect normal cells from the side effects of chemotherapy. PURPOSE: This phase I trial is studying the side effects, best way to give, and best dose of high-dose methotrexate in treating patients with solid tumors.
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