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Toward Molecular Capture of Sulfatase–Heparan Sulfate Interactions: Development of Bifunctional Azide–Sulfamate Probes Exploiting the Formylglycine Catalytic Mechanism

Pan, Guangfei
eScholarship · Papers
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biochemistrychemistryorganic-chemistry
The human extracellular endosulfatases Sulf-1 and Sulf-2 remodel heparan sulfate (HS) after its biosynthesis by selectively removing 6-O-sulfate groups from internal glucosamine residues, thereby altering the sulfation patterns that regulate growth-factor signaling. How these enzymes recognize indiv
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