synuclein

Documents about synuclein

• Alpha-synuclein-decorated nanoconjugates targeting alpha-synuclein assembly#374373HAL (France)
• The α-synuclein proteostasis network and its translational applications in Parkinson's disease.#314187Apollo
• Systemic Synuclein Sampling Study (S4)#843230ClinicalTrials.gov
• Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction#448974Infoscience
• DT-diaphorase protects against autophagy induced by aminochrome dependent alpha synuclein oligomers#646954Repositorio Académico de la Universidad de Chile
• Open-label Study to Evaluate Brain α-Synuclein Deposition Using PET and [18F]MK-0947 in Parkinson's Disease#890435ClinicalTrials.gov
• MULTI-MODAL CHARACTERIZATION OF ALPHA-SYNUCLEIN AND ITS BINDING PARTNERS ACROSS CONFORMATIONAL STATES#929469ScholarlyCommons
• Diagnostic Potential of Combined Skin Morphometric Analysis and Salivary Alpha-Synuclein Oligomers in Parkinson's Disease#120143Europe PMC
• α-Synuclein Interaction with Lipid Bilayer Discs#391932HAL (France)
• Inducing β-hairpin and α-helix folding in peptides : design, synthesis and evaluation of α-synuclein and tau aggregation inhibitors#254254HAL (France)
• S100A9 Alters the Pathway of Alpha-Synuclein Amyloid Aggregation#933924MIDAS OAI-PMH
• Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies#124314HAL (France)
• Transcriptional regulation of α-synuclein by TRIM17, TRIM41 and ZSCAN21 pathway in Parkinson’s disease#231574HAL (France)
• A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies#828717ClinicalTrials.gov
• Connexin 43 hemichannels and pannexin-1 channels contribute to the α-synuclein-induced dysfunction and death of astrocytes#947813Repositorio de Universidad Autónoma de Chile.
• Modulators Selectively Reshape alpha-Synuclein Phase Transitions#987552arXiv (All)
• Hyphenated Mass Spectrometry-based Strategies for Characterizing Oligomers of alpha-Synuclein in Parkinson’s Disease#241329Yoda MOAI Feed
• Synuclein and dopamine transporter biomarkers among phenoconverters to parkinsonian disorders#200187bioRxiv / medRxiv
• G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice#280375HAL (France)
• STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF N-TERMINALLY ACETYLATED ALPHA-SYNUCLEIN#929475ScholarlyCommons
• Alpha-synuclein fibrils induce budding of mitochondrial-derived vesicles.#288808NCBI PubMed Central
• α-Synuclein strain homogeneity in multiple system atrophy subtypes.#458629NCBI PubMed Central
• Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent#368904SUNScholar
• Membrane interfacial potential governs surface condensation and fibrillation of α-Synuclein in neurons#190378PMC Full-Text (OAI)
• α-Synuclein Facilitates Spontaneous Dopamine Release in a Calcium- and Phosphorylation-Dependent Manner#214786bioRxiv / medRxiv
• Utilizing Intraindividual Cognitive Variability to Predict Stage 2 Neuronal Synuclein Disease Progression#241493bioRxiv / medRxiv
• Atrophy signature for alpha-synuclein copathology in Alzheimer's disease.#269580NCBI PubMed Central
• De novo Design of Polymorph-Specific Binders Targeting α-Synuclein Fibrils#294788Infoscience
• α-Synuclein Forms Distinct Micelle-Like Assemblies at Low Ionic Strengths.#479341NCBI PubMed Central
• Inhibition of α-synuclein Cell-cell Transmission by NMDAR Blocker, Memantine#872886ClinicalTrials.gov
• Elucidating the role of post-translational modifications of alpha-synuclein using semisynthesis : phosphorylation at Tyrosine 125 and monoubiquitination at Lysine 6#320072DataCite
• Ferroptosis links α-synuclein pathology across brain and skeletal muscle in Parkinsons disease#165968bioRxiv / medRxiv
• Synaptic vesicle architecture modulates α-synuclein conformation and pathogenic transitions in Parkinson's disease.#285118NCBI PubMed Central
• Effects of α-synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging.#154173NCBI PubMed Central
• Integrating α-Synuclein Seeding Activity (SAA) into routine practice: insights from the multicenter ALZAN Cohort#216677bioRxiv / medRxiv
• Connexin 50 mediates disease-relevant alpha-synuclein oligomer propagation and neuroinflammation in neurodegenerative disease.#315757NCBI PubMed Central
• Lipid droplets promote aberrant liquid-liquid phase separation of alpha-synuclein impairing energy homeostasis.#449949NCBI PubMed Central
• α-Synuclein aggregates in corticostriatal terminals impair glutamatergic transmission in the absence of neurodegeneration#657277bioRxiv / medRxiv
• Design and Development of Peptide Inhibitors Targeting Alpha-Synuclein for Parkinson’s Disease#246148DigitalCommons@Kennesaw State University
• Clinical progression in alpha-synuclein positive LRRK2-PD and sporadic Parkinsons disease: a longitudinal analysis#29783bioRxiv / medRxiv
• α-Synuclein aggregates induce mitochondrial damage and trigger innate immunity to drive neuron-microglia communication#347838HAL (France)
• Structurally targeted mutagenesis identifies key residues supporting α-synuclein misfolding in multiple system atrophy#372156PubMed Central
• Early α-Synuclein Pathology Induces Neuroinflammation and Decreases Topoisomerase IIβ Expression in A53T Mice#397889Aperta
• Redox activity of α-synuclein-Cu is silenced by Zn(7)-metallothionein-3#403855DataCite
• α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson's disease#669705Europe PMC
• α-Synuclein aggregation and brain atrophy in SNCA-A53T transgenic monkeys are correlated with parkinsonism.#670979NCBI PubMed Central
• Biomarkers in Parkinsonian Syndromes#1010379ClinicalTrials.gov
• Consistency of Serial CSF alpha-Synuclein Seed Amplification Assay Results in the Parkinson's Progression Marker Initiative#150420bioRxiv / medRxiv
• Alpha-synuclein co-pathology amplifies amyloid-driven tau accumulation across Braak stages without modifying tau-cognition associations#154904bioRxiv / medRxiv
• Characterising extracellular ⍺-synuclein and its associated release mechanisms in hiPSC-derived dopamine neurons#228160Ora Oxford University Research