Aβ1-40 induces venular endothelial cell ferroptosis in cerebral amyloid angiopathy via the ATF3/xCT axis: Insights from single-cell RNA sequencing

Introduction Amyloid-beta (Aβ)-induced microvascular injury is a key pathological feature of cerebral amyloid angiopathy (CAA). Recent evidence suggests that ferroptosis is implicated in Aβ pathology; however, its cell-type specificity and regulatory mechanisms within the cerebral microvascu