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SARS-CoV-2 defective viral genomes from distinct genomic regions drive divergent interferon responses

Justin W. Brennan et al.
PLOS · Papers · License: CC BY 4.0
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genomicsinterferonssars-cov-2
Defective viral genomes (DVGs) are generated during the genomic replication of many RNA viruses. When produced early in infection or supplemented at the onset of infection, DVGs can attenuate viral pathogenesis by stimulating interferon responses and antagonizing wild type (WT) virus replication, h
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